![]() The underlying mutation of the cystic fibrosis trans-membrane regulator gene depletes functional cystic fibrosis trans-membrane regulator on the surface of epithelial cells lining the digestive tract and associated organs, where Cl− secretion and subsequently secretion of water and other ions are impaired. Larger studies of longer duration are needed to determine whether DHA supplementation results in any clinically significant benefits in patients with CF.Ĭystic fibrosis can affect food digestion and nutrient absorption. No adverse developments were associated with this large dose of DHA oil. DHA supplementation had no detectable effect on lung function during the course of this study.Īlgal DHA triacylglycerol oil is readily absorbed, well tolerated, and increases blood and tissue DHA levels in patients with CF. Supplementation was well tolerated, with no treatment-related changes in liver enzymes, growth, or antioxidant status. Lung function, anthropometrics, and adverse experiences were monitored throughout the study.Ĭompared with placebo, DHA supplementation increased plasma, erythrocyte, and rectal DHA levels four- to five-fold (P < 0.001) with concomitant decreases in blood arachidonic acid levels and the ratio of arachidonic acid to DHA. ![]() Rectal biopsy specimens were collected at baseline and at 3 mo for fatty acid analysis. Fatty acids, liver enzymes, and lipid soluble antioxidants were measured in blood at baseline and at 1, 3, and 6 mo. Twenty subjects with CF (8 to 20 y of age) were randomly assigned to receive algal oil providing 50 mg of DHA per kilogram per day (1 to 4.2 g of DHA per subject per day) or placebo for 6 mo. ![]() The study objective was to determine bioavailability, tissue accretion, and safety of a large dose of an algal source of docosahexaenoic acid (DHA) triacylglycerol and to observe effects on lung function in patients with CF. Whether these imbalances contribute to or are manifestations of the pathophysiology of CF is unknown. Several studies have reported omega-3 and omega-6 fatty acid imbalances in patients with cystic fibrosis (CF).
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